WiSE CRT System's unique approach

The WiSE CRT System uses proprietary wireless technology to pace the left ventricle endocardially and deliver personalized pacing therapy to patients. Offering a versatile and leadless design, the WiSE System brings a more physiologic approach for physicians to treat patients.

EBR - FDA Approval Badge

JAMA Cardiology publishes EBR’s pivotal SOLVE-CRT study

SOLVE-CRT Study demonstrated that leadless left ventricular endocardial pacing (LVEP) with the WiSE CRT System is associated with a reduction in LVESV in heart failure patients.

Empowering physicians, powering hearts

The WiSE CRT System is designed to overcome the limitations of conventional CRT and is the only leadless left ventricular endocardial pacing (LVEP) device.

Side view

Home illustration

Anchor

Retains Electrode during endothelization

Electrode

Converts ultrasonic energy into electrical pulse

Exterior

Polyesterjacket for rapid endothelization

Device body

9.3 mm body length, 0.04 cc volume

Cathode

Maps thresholds pre-anchoring, delivers pacing pulse when anchored

Top view

2.8 mm diameter

How it works

The WiSE CRT System is designed to work with patients' existing implant(s) to provide leadless CRT 

Home illustration
2

Battery

Subcutaneous device ensures steady energy to the Transmitter
3

Transmitter

  • The “brains” of the system—a subcutaneous device
  • Detects co-implant pacing pulse
  • Within milliseconds, sends ultrasonic energy to power the Electrode
4
Electrode
  • Converts ultrasonic energy into electrical pulses
  • 0.05 cc leadless device features a polyester jacket for rapid endothelization (<45 days)
1
Co-implant
Delivers conventional pacing
Icon: Versatile

Versatile

Open platform coordinates therapy
with a range of existing pacing devices

Icon: Leadless

Leadless

Ultra-compact leadless device removes constraints of lead-based pacing systems

Icon: LV Endocardial

LV Endocardial

More physiologic approach via left ventricle endocardial pacing (LVEP) for CRT

How it works

The WiSE CRT System is designed to work with patients' existing implant to provide bi-ventricular pacing.

Icon: Co-implant

Co-implant

  • Delivers conventional pacing
Icon: Battery

Battery

  • Subcutaneous device ensures steady energy to the Transmitter
Icon: Transmitter

Transmitter

  • Detects co-implant pacing pulses
  • Within milliseconds, sends ultrasonic energy to power the Electrode
Icon: Electrode

Electrode

  • Converts ultrasonic energy into electrical pulses
  • 0.05 cc leadless device features a polyester jacket for rapid endothelization (<45 days)
Icon: Arrow leftIcon: Arrow right
Home illustration

Procedure workflow

Three procedural stages occur to achieve optimal clinical outcomes:

1. Pre-assessment

Optimize location for ultrasound transmission to the left ventricle.

2. Surgical Implant

Surgically place Transmitter & Battery per pre-assessment optimization.

3. Electrode Mapping & Anchoring

Map left endocardial surface and implant Electrode with a single delivery system.

Current patents

The WiSE CRT System (also known as the WiSE System), and any other product(s) listed on this internet posting, either alone or in combination with other product(s), may be protected by one or more of the identified U.S. patents. Each product may also be protected by one or more patents issued outside of the U.S., and additional patent applications related to one or more of the listed products may be pending in the U.S. or elsewhere. The absence of a product name or patent number associated with any listed product does not constitute a waiver of EBR Systems’ intellectual property rights concerning that product or patent. This internet posting is intended to serve as notice under 35 U.S.C. § 287(a).

U.S. Patents

US 7,558,631
US 7,606,621
US 7,610,092
US 7,765,001
US 7,809,438
US 7,848,815
US 7,890,173
US 7,996,087
US 8,315,701
US 8,364,276
US 8,588,926
US 8,634,908
US 8,718,773
US 9,008,776
US 9,014,803
US 9,283,392
US 9,333,364
US 9,343,654
US 9,616,235
US 9,855,429
US 9,180,285
US 9,907,968
US 9,981,138
US 10,052,493
US 10,080,903
US 10,207,115
US 10,456,588
US 10,512,785
US 10,576,287
US 10,688,307
US 10,806,938
US 11,376,439
US 11,452,879
US 11,712,572
US 11,752,352
US 12,133,983

O.U.S Patents

EP 1833553
EP 1835964
EP 2069012
EP 2148640
EP 2265166
EP 2268352
EP 2452721
EP 2544761
JP 5111116
JP 5153343
JP 5462848
JP 5519056
JP 5572088

The WiSE impact:

"The best agency we’ve worked with so far. They understand our product and are able to add new features with a great focus."

Jenny Wilson
Vice President

The WiSE impact:

"EBR Systems has truly revolutionized cardiac rhythm management with their groundbreaking WiSE technology."

Brennan Miller
Vice President